Which of the following streets has the highest numerical designation?

The street with the highest numerical designation among the options provided is Chicago. In the context of street naming and numbering in urban areas, the designation of a street can be influenced by historical naming conventions and urban planning.

In Chicago, street names are often derived from historical figures, geographical features, or significant local history. However, when comparing streets based simply on their numerical designation within the city's grid system, Chicago is a major thoroughfare and can be understood as holding a higher numerical significance in the urban layout due to its prominent role in the city.

The other streets listed, such as Ontario, Erie, and Huron, while they are important in their own right, do not denote the same level of central significance or numerical value when considered alongside Chicago. This context helps clarify why Chicago stands out not just as a street name, but also in terms of its prominence and numerical designation within the broader city infrastructure.